Use state-of-the-art chemistry techniques for radiochemical applications, including performing the synthesis and quality control (QC) analysis of radiopharmaceuticals for preclinical evaluation and clinical PET imaging; performing multi-step radiosyntheses using automated chemistry modules and characterizing products for QC using analytical techniques such as liquid chromatography (LC), gas chromatography (GC), radio-TLC, endosafe endotoxin testing, dose calibrators, mass spectrometry; cyclotron operation to produce positron-emitting radionuclides; synthesis and quality control of PET tracers to meet demanding pre-clinical and clinical imaging schedules according to pertinent state and federal regulations; development and cGMP validation of new radiosyntheses; contributing to regulatory documents (e.g. Investigational New Drug (INDs) applications, Non-Disclosure Agreement (A)NDA)) required for clinical PET tracer filings; assist with writing peer-reviewed manuscripts and presenting data at research conferences; operate and maintain PET radiochemistry laboratory equipment (e.g. radiochemistry synthesis modules, radio-HPLC and TLC systems, GC systems); mentor and train junior laboratory staff and trainees; assist with regulatory and quality initiatives, monitoring, inspections and correspondence with regulatory agencies; maintain accurate record keeping for lab books, equipment logbooks and production batch records; collaborate with PET Center and imaging suite; coordinate processing and analysis of data and the conduct of experimental tests; suggest new or revised analytical methodologies; provide input into the development of mathematical and/or computer models for analyzing experimental data; train users in equipment operation and laboratory techniques.
Master's in Pharmaceutical Sciences, Chemistry, or related.
5 years analytical chemistry research experience using, planning, and executing complex analyses of bioactive molecules and pharmaceutical samples.
Experience must include characterizing products by spectroscopic and chromatographic methods, including IR, NMR, Mass spectral (MS), High Performance Liquid Chromatography (LC), gas chromatography (GC) and/or hybrid GC-MS and LC-MS data. 1 publication in peer-reviewed professional journal.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third-party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act.
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
A great university is made so by its faculty and staff, and Michigan is recognized as one of the best universities to work for in the country. The Michigan culture is known for engaging faculty and staff in all facets of the university to create a workplace that is vibrant and stimulating.For two consecutive years, the Chronicle of Higher Education has placed U-M in its "Great Colleges to Work For" survey. In particular, the university earns high marks for strong relations between faculty and administrators, a collaborative system of governance, strong pay and benefits, and a healthy work/life balance.