We are looking to hire a Senior Scientist (Medicinal Chemistry and Drug Discovery) in the Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston. Thakur Lab has been at the forefront in the development of GPCR (cannabinoid receptors 1 and 2) allosteric modulators of GPCR receptor as well ligand-gated ion channel for the treatment of several diseases. Such a candidate will support the preclinical drug discovery and development for early-stage therapeutic for the treatment of neuropathic pain, glaucoma, epilepsy and substance use disorder.
As a member of a small team, this Senior Scientist is expected to execute across all aspects of medicinal chemistry. The candidate will be is responsible for designing, synthesizing, and optimizing molecules targeting GPCRs (cannabinoid receptors; allosteric and orthosteric) and ion channels (a4b2 nAChR, a7nAChR, GIRK1/2, GIRK1/4etc.). Key initial responsibilities will include data analysis, SAR hypothesis generation, empirical and structure-based target design, and synthetic chemistry and troubleshooting.
Our main focuses are to improve the potency/efficacy and physicochemical as well aspharmacokinetics properties of the hit molecules through chemical modification. Besides, the candidate will also work on the submission of manuscripts, patents, group reports and providing scientific seminars as well as mentoring and assisting junior researchers in the lab.
We are seeking a highly motivated and talented Medicinal Chemist with strong technical and problem-solving skills in organic and medicinal chemistry.
Ph.D. in organic or medicinal chemistry with at least 3 years of relevant research experience with strong scientific knowledge.
The candidate should have a broad understanding of GPCR signaling, allostericparameters, plotting and interpretation of data, ADME, LC-MS and an ability to develop and deliver clear and concise presentations for both internal and external meetings. Hands-on experience in GPCR signaling assays, electrophysiology assays and in-vitro/in vivo ADME/PK evaluation will be a plus. The candidate should have a strong publication record in synthetic organic and medicinal chemistry and outstanding written and verbal communication skills.
Northeastern University is an equal opportunity employer, seeking to recruit and support a broadly diverse community of faculty and staff. Northeastern values and celebrates diversity in all its forms and strives to foster an inclusive culture built on respect that affirms inter-group relations and builds cohesion.
All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, religion, color, national origin, age, sex, sexual orientation, disability status, or any other characteristic protected by applicable law.
Founded in 1898, Northeastern University is a private research university located in the heart of Boston. Northeastern is a leader in worldwide experiential learning, urban engagement, and interdisciplinary research that meets global and societal needs. Our broad mix of experience-based education programs?our signature cooperative education program, as well as student research, service learning, and global learning?build the connections that enable students to transform their lives. The University offers a comprehensive range of undergraduate and graduate programs leading to degrees through the doctorate in nine colleges and schools.