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Details
Posted: 31-Jan-23
Location: Irvine, California
Type: Full-time
Salary: Open
Internal Number: 3844395
University of California Irvine
Project Scientist - Neurotherapeutics Institute
We seek a doctorate level or equivalent degree project scientist with substantial experience using computer aided drug (CADD) design techniques to guide library screening and lead optimization efforts. The ideal candidate will have ample experience with diverse tools in a pharmaceutical industry context or similar, with a thorough understanding of the available methods and their pros and cons, as well as experience interacting with both academic and industry collaborators in a discovery setting. In this position, the project scientist will engage in modeling efforts to guide ongoing screening and lead optimization work, as well as engaging with graduate student and postdoctoral researchers in participating computational labs to help them engage in ongoing modeling efforts and bring new techniques to bear in screening.
In this role, the project scientist will provide a hub or bridge between different experimental efforts and available computational resources, both those the project scientist can provide through their own expertise and skill, and those available elsewhere on campus, such as in the Mobley lab. The project scientist will work under the oversight of Dr. Mobley but engage frequently (ideally sharing space with and continually engaging with) the participating experimental groups to provide ongoing modeling guidance to discovery projects, with the goal of tightly integrating modeling and experiment.
PREFERRED QUALIFICATIONS (but not required for the position)
A candidate should have experience with diverse technologies and tools in the CADD space, including:
Virtual screening techniques (fingerprinting, docking, shape-based, pharmacophore modeling, etc.)
Tools for guiding lead optimization, including potentially molecular dynamics simulations, binding free energy calculations, QSAR modeling, etc.
Substantial skill with structure-based design, including ample experience preparing/validating protein structures for modeling, assessing/assigning protonation states, building in missing residues/loops, etc.
Experience with building/using homology models
Experience working with medicinal chemists and considering synthetic accessibility and metabolic issues would be a significant plus
Other preferred qualifications include:
Excellent Python skills
Scientific software development experience
Familiarity with open source software development, continuous integration testing, etc.
Experience with git and version control systems, e.g. including GitHub
Experience working with both academic and vendor-supported software
Comfortable working with diverse high performance computing resources and queueing systems in a Linux-based environment
Comfortable using, and building workflows with, diverse software types including GUI-based, command-line-based and API-based frameworks.
A reasonable estimate for this position is $68,400-$180,200. https://ap.uci.edu/wp-content/uploads/projSci.pdf 'Off-scale salaries' and other components of pay, i.e., a salary that is higher than the published system-wide salary at the designated rank and step, are offered when necessary to meet competitive conditions.
To apply, please log into: UCI Recruit: https://recruit.ap.uci.edu/JPF08077 to upload Cover letter, CV and Inclusive Excellence/Contributions to Diversity Statement.
To apply, visit https://recruit.ap.uci.edu/JPF08077
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Since 1965, the University of California, Irvine has combined the strengths of a major research university with the bounty of an incomparable Southern California location. UCI's unyielding commitment to rigorous academics, cutting-edge research, and leadership and character development makes the campus a driving force for innovation and discovery that serves our local, national and global communities.
More Jobs from This Employer
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