The laboratory of Dr. Andrew R. Marks, Chair, Department of Physiology and Cellular Biophysics at Columbia University Irving Medical Center, is seeking 3 Postdoctoral Research Scientists (see Markslab.org). Projects include: cryo-EM structures of RyR channels, calcium signaling in cardiovascular, metabolic and neurodegenerative disorders. We are translating fundamental discoveries into ongoing clinical trials. Recent laboratory members have gone on to leading academic and pharmaceutical industry positions.

Selected publications include:

Liu, X., Betzenhauser, M.J., Reiken, S., Meli, A.C., Arancio, O., Chen B.-X., Marks AR (2012) Role of Leaky Neuronal Ryanodine Receptors in Stress-Induced Cognitive Dysfunction Cell 150, 1055–1067.

Ran Zalk, Oliver B. Clarke, Amédée des Georges, Robert A. Grassucci, Steven Reiken, Filippo Mancia, Wayne A. Hendrickson, Joachim Frank, Marks, A.R. (2014) Structure of a mammalian ryanodine receptor Nature 2015 517(7532):44-9.

Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA Excess TGF-Beta mediates muscle weakness associated with bone metastases in mice. Nature Medicine, 2015 Nov;21(11):1262-1271.

des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank, J Structural Basis for Gating and Activation of RyR1. Cell 2016 Sep 22;167(1):145-157

Melville Z, Kim K, Clarke OB, Marks AR. High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor. Structure. 2021 Aug 26:S0969-2126(21)00296-3. doi: 10.1016/j.str.2021.08.001. Online ahead of print. PMID: 34469755

Competitive salaries and potential positions on our NIH funded T32 training grants available.

All applicants should have a PhD or MD/PhD, outstanding publications, oral and written communication skills, organizational skills, work ethic, and the ability to work independently. 

All applicants must apply online.

Please email a curriculum vitae and contact information for three references to: Dr. Andrew R. Marks andrewmarksoffice@cumc.columbia.edu

Columbia University is an Equal Opportunity Employer / Disability / Veteran

About Columbia University

Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.

Connections working at Columbia University