Please send a cover letter and CV to Dr. Tessier via email to ptessier@umich.edu

The University Of Michigan, College Of Pharmacy has a full-time opening for a research fellow in the Tessier Lab within the Pharmaceutical Sciences department. Monoclonal antibodies are being widely used for therapeutic applications and represent most of the current best-selling drugs. However, it remains challenging to identify antibodies early in the discovery and optimization stages that possess drug-like biophysical properties, including high solubility and low viscosity when formulated at high concentrations for subcutaneous delivery. The goal of this project is to develop novel methods for high-throughput screening of the biophysical properties of monoclonal antibodies. This project will be in collaboration with biopharma and will provide an excellent opportunity for postdoctoral candidates to be exposed to leading scientists in the biotech industry.

Monoclonal antibodies are being widely used for therapeutic applications and represent most of the current best-selling drugs. However, it remains challenging to identify antibodies early in the discovery and optimization stages that possess drug-like biophysical properties, including high solubility and low viscosity when formulated at high concentrations for subcutaneous delivery. The goal of this project is to develop novel methods for high-throughput screening of the biophysical properties of monoclonal antibodies. This project will be in collaboration with biopharma and will provide an excellent opportunity for postdoctoral candidates to be exposed to leading scientists in the biotech industry.

The duties of this position involve using molecular biology, cell culture, biochemistry and biophysical screening methods to generate and evaluate the biophysical properties of monoclonal antibody variants. The experimental methods that will be used in this project include protein expression, protein purification, mammalian cell culture, flow cytometry, dynamic light scattering, nanoparticle-based methods for detecting self-association, and antibody biochemical/biophysical characterization.

PhD in engineering, life sciences, pharmaceutical science, chemistry, physics or related fields. Required skills include some experimental experience related to evaluating the biochemical or functional properties of proteins.

Some experience with molecular biology/biochemistry or biophysical characterization of proteins.

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