Specialist Position - Manglik Lab
Department of Pharmaceutical Chemistry
University of California, San Francisco

The Department of Pharmaceutical Chemistry is seeking a Specialist at the Junior or Assistant rank, in the laboratory of Dr. Aashish Manglik. Our lab’s primary interest is to understand how cells and organisms sense and respond to their outside environment. We study the signaling molecules that enable cells to communicate with each other. We apply biochemistry, biophysics, structural biology, pharmacology, and protein engineering to discover how proteins sense external stimuli and induce cellular signaling. We are especially interested in cellular signaling at the intersection of human health and disease. For example, we have recently shown how molecules act at various receptors at atomic level detail, and have used these insights to engineer new drugs with improved therapeutic properties.

The candidate will work with senior scientists in the lab to conduct biochemical and biophysical experiments to understand cellular signaling proteins. Key responsibilities will include executing experiments, creating reports, and communicating with members of the laboratory. Exceptional candidates will be able to lead an independent project.

Required Qualifications:
• Well-developed organization and communication skills
• Desire to learn new skills, approaches, and techniques
• Aptitude to work independently or collaboratively with others
• Ability to prioritize tasks, coordinate tasks with others, and meet deadlines
• Specialists appointed at the Junior rank must possess a baccalaureate degree (or equivalent degree) or at least four years of lab research experience
• Specialists appointed at the Assistant rank must possess a master’s degree (or equivalent degree) or at least five to ten years of lab research experience
• Candidates must meet the requirements by the time of appointment. CV must list pending requirements.

Preferred Qualifications:
• Prior experience with protein biochemistry and some exposure to structural biology
• Prior experience with eukaryotic cell culture techniques
• Detailed knowledge of molecular biology techniques, including DNA construct design and cloning, DNA purification, immunoprecipitation

Please apply online at https://aprecruit.ucsf.edu/JPF03991 with a CV, cover letter, and the contact information of 3 references.

We are seeking candidates who can provide a 1-year commitment. Significant growth opportunities are available with longitudinal commitment, including ambitious independent research projects, mentorship roles for trainees, and exposure to manuscript and grant writing