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Research Fellow/Senior Research Fellow (Nutrition) SIFBI
The developing fetus is highly sensitive to the exposure of substances present in maternal blood during gestation, which in part is controlled by the placental barrier. However, it remains extremely challenging to precisely quantify fetal exposure to both essential nutrients and harmful chemicals, which dictate the optimal doses for supplementation and safe exposure limits. We intend to develop a physiologically-based pharmaco/nutri/toxicokinetic (PBPK/PBNK/PBTK) model to predict the human placental transfer and fetal disposition of xenobiotics in pregnancy. This project combines both in vitro assay development and in silico mathematical modelling to generate robust PBPK/PBNK/PBTK models that can be applied in both nutritional and safety contexts. The candidate


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