Medical Affairs Postdoctoral Fellow

About the Opportunity

The Northeastern University Biopharmaceutical Industry Fellowship Program provides a dynamic academic environment offering fellows the opportunity for a wide breadth of experiences:

• Develop teaching skills through participation in our Teaching and Learning Seminar series
• Facilitate small and large group didactic education in partnership with a faculty mentor
• Utilize a layered learning model in experiential education by co-precepting students on pharmacy practice experiences including Northeastern's unique co-op program
• Create, present, and publish scholarly research through collaborative industry and university relationships
• Engage with faculty who participate in various interdisciplinary graduate programs including biotechnology, nanomedicine, immunology, health informatics, and drug discovery
• Network with area residents and other Northeastern fellows via professional development programs, teaching seminars, and participation on fellowship committees

About Partner/ Company:

X4 Pharmaceuticals is a late-stage clinical biopharmaceutical company and a leader in the discovery and development of novel therapies for the treatment of diseases of the immune system via antagonism of the CXCR4 pathway, with a focus on rare diseases and those with limited treatment options. We believe that inhibition of the CXCR4 receptor creates the potential to provide therapeutic benefit across a wide variety of diseases, including primary immunodeficiencies and certain types of cancer.

Our lead clinical candidate, mavorixafor, is a first-in-class, small molecule antagonist of chemokine receptor CXCR4 being developed as a once-daily oral therapy. We are currently evaluating the safety and efficacy of mavorixafor in a Phase 3 clinical trial for the treatment of patients with WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. To date, mavorixafor has demonstrated proof-of-concept in WHIM syndrome in a Phase 2 clinical trial, including clinically meaningful increases in neutrophil and lymphocyte biomarker counts, as well as a trend of reduction in infection rates and wart burden, and has been generally well tolerated. Enrollment in the Phase 3 WHIM clinical trial is now complete and top-line clinical results are expected in the fourth quarter of 2022. For the WHIM indication, mavorixafor has been granted Breakthrough Therapy Designation, Fast Track Designation, and Rare Pediatric Designation in the U.S., and Orphan Drug Status in both the U.S. and European Union

We are also studying mavorixafor in two Phase 1b clinical trials - one in combination with ibrutinib in patients with a rare B-cell lymphoma called Waldenstrom macroglobulinemia, and the other as a monotherapy in patients with Severe Congenital Neutropenia (SCN) and other chronic neutropenia disorders.

X4 is a global company headquartered in Boston, Massachusetts with research offices based in Vienna, Austria.At X4 our mission is to develop treatments that have a clear and profound impact for patients suffering with rare diseases, including primary immunodeficiencies (such as WHIM syndrome) and cancer. We are developing potential new treatments through a rigorous R&D process for diseases where we believe we can dramatically improve the overall health of patients. Yet, we know that developing innovative, new medicines is highly challenging. So, as a fundamental part of our values, we seek to bring grit to all of our efforts. Our core values define us and act as guideposts for our thoughts, behaviors and decisions every day. We strive to:

Excellence

Do all things with rigor.

Accountability

Hold each other and ourselves accountable for our actions and to live our values.

Camaraderie

Work together as a team aligned to achieve our goals and be respectful of each other.

Integrity

Act with honesty and transparency.

Sense of Urgency

Demonstrate a higher sense of purpose: to alleviate human suffering and cure disease

Grit

Move forward with firmness of mind and unyielding courage

Please visit https://www.x4pharma.com/for additional information.

Responsibilities:

Overview of Job Responsibilities: Global Medical Affairs Fellowship

X4's grit and science drive solutions for patients. Every day, the company strives to advance the pipeline of innovative therapeutic candidates to treat rare diseases. The focus is on targeting the CRCX4 pathway, one of the most important chemokine receptor pathways, in an effort to treat people living with rare immune system disorders.

If you want to make a broader impact on the healthcare community, join our Global Medical Affairs Fellowship.

Global Medical Affairs at X4 Pharmaceuticals will provide medical affairs support across the asset lifecycle, starting with early clinical development in Primary Immunodeficiency Diseases (PID) and Chronic Neutropenia (CN), through insight generation, evidence generation, and medical communication. The two-year X4 Pharmaceuticals Global Medical Affairs Fellowship Program is designed to prepare postdoctoral fellows for rewarding careers in the biopharmaceutical industry. Through hands-on experience, fellows will work with various cross-functional teams to learn the role of Medical Affairs, as well as develop skills in the analysis, interpretation, and communication of clinical data. The fellow will expand their scientific knowledge to render clinical insights and to inform healthcare providers of the most relevant data available to best treat their patients.

The Global Medical Affairs fellow will gain valuable experience as a key member of teams within various functional areas and departments under the mentorship of Global Medical Affairs leadership. Fellows will have the flexibility to select activities based on interest and company needs in order to enhance learning and personal growth. These may include, but are not limited to, projects in Medical Strategy, Communication, Operations, Information, Field Medical Affairs, and Health Economics and Outcomes Research. Throughout both years of the fellowship program, there will be mentorship opportunities via one-on-one interactions with Global Medical Affairs and other cross-functional leaders.

Upon completion of the program, fellows will have both broad and deep experience in Medical Affairs and be well poised for a successful career in the biopharmaceutical industry.

The fellows will primarily work at X4 Pharmaceuticals' office in Boston, Massachusetts. Northeastern University responsibilities will be carried out on the Northeastern Boston campus.

Qualifications:

Doctor of Pharmacy degree from an ACPE accredited institution, eligible for licensure as a pharmacist in the State of Massachusetts.

Excellent oral and written communication, time management, and leadership skills, ability to work independently and take initiative on a variety of projects at the industry site and Northeastern.

Additional Information:

Applicants should submit the following APPLICATION MATERIALS by the priority deadline of March 18th, 2022:

Curriculum vitae (CV), uploaded Unofficial PharmD transcripts, uploaded Cover letter, uploaded

Three formal letters of recommendation (LORs) sent directly from the letter writer to PharmDFellowships@northeastern.edu by March 18th, 2022 LOR writers should include the candidate's name and fellowship program(s) in the subject line (e.g. Smith, John - Alnylam, GSK).

Address cover letter and three LORs to:

J. Andrew Orr-Skirvin, PharmD, BCOP

Clinical Professor, School of Pharmacy

Chair, Department of Pharmacy & Health System Sciences

Director of Pharmaceutical Industry Fellowship Program

360 Huntington Ave, 140TF R218

Boston, MA 0211

Position Type

Research

Additional Information

Northeastern University is an equal opportunity employer, seeking to recruit and support a broadly diverse community of faculty and staff. Northeastern values and celebrates diversity in all its forms and strives to foster an inclusive culture built on respect that affirms inter-group relations and builds cohesion.

All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, religion, color, national origin, age, sex, sexual orientation, disability status, or any other characteristic protected by applicable law.

To learn more about Northeastern University's commitment and support of diversity and inclusion, please see www.northeastern.edu/diversity.


To apply, visit https://northeastern.wd1.myworkdayjobs.com/en-US/careers/job/Boston-MA-Main-Campus/Medical-Affairs-Postdoctoral-Fellow_R102266





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