The Department of Pharmaceutical Chemistry is one of the three research and teaching departments in the School of Pharmacy (SOP) at UCSF. As part of its research mission, Dr. England's research laboratory focuses on developing chemical tools for decoding biology and advancing medicine. The laboratory is currently developing small molecules to control the activity of nuclear receptors, a class of intracellular proteins that regulate gene expression in response to endogenous hormones and other small molecules. These receptors play critical roles in human development, physiology, and disease and have proven to be effective therapeutic drug targets.
The Staff Research Associate II (SRA II) will characterize the interaction of small molecules with the nuclear receptor Nurr1, a potential therapeutic target for Parkinson's disease. These interactions will be measured using one or more common biophysical methods such as surface plasmon resonance (SPR), microscale thermophoresis (MST), Forster resonance energy transfer (FRET), protein NMR spectroscopy, protein crystallography.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.