C4 Therapeutics is pioneering a new class of drugs. C4T’s technology platform produces small molecule drugs that harness machinery already present in cells to selectively target disease-relevant proteins for degradation. Our approach has the potential to address a broad range of diseases including cancer, infectious disease, and autoimmune disorders. We are excited to be building the organization that will take the next step in leading this new class of drugs from research into drug development and clinical trials.
C4 Therapeutics is seeking an experienced DMPK scientific leader at the Associate Director/Director level to lead the discovery and development of small molecule therapeutics that enable the Ubiquitin-Proteosome System (UPS)-mediated degradation of proteins implicated in disease. Reporting to the Head of DMPK, you will be responsible for managing internal and external DMPK efforts, problem-solving, and ongoing nimble integration of DMPK discipline into C4T’s advancing portfolio. The successful candidate will develop ADME strategies, engage teammates across functions, and build partnerships with external collaborators to help rapid advancement of drugs from discovery through preclinical development.
You will lead DMPK efforts on C4T drug discovery projects ranging from lead optimization to candidate selection through generation, analysis, and interpretation of ADME data.
Integrate and report preclinical DMPK data both internally and with external collaborators
Lead the preclinical assessment of ADME properties, including metabolism and pharmacokinetic properties of lead candidates
Collaborate cross-functionally to establish PK-PD-efficacy correlations, selection of preclinical Tox species and toxicokinetics
Mentor scientific staff
Manage CROs to ensure quality and timely delivery of ADME data
Additional duties and responsibilities as required
Ph. D. in pharmaceutical or related discipline with ≥ 7 years industry experience or an MS in pharmaceutical sciences or related disciplines with ≥ 10 years of industry experience in a DMPK setting.
You will have a broad understanding of the role of DMPK function in drug discovery and development.
Demonstrable experience of leading DMPK efforts from discovery through preclinical development
Excellent oral and written communication skills, the ability to work as an effective team member in a highly collaborative work environment, and the ability to lead and influence
Experience in Biotransformation and metabolite identification and characterization studies a plus
Experience working with contract research organizations
Supervisory experience highly desirable
Familiarity with current FDA and EMA guidelines a plus
Self-starter and independent thinker
Ability to multi-task and work in a fast-paced environment.
C4 Therapeutics is an Equal Opportunity Employer.
Please submit your job application at https://c4therapeutics.bamboohr.com/jobs/view.php?id=56
Internal Number: DMPK
About C4 Therapeutics
C4 Therapeutics (C4T) is a biopharmaceutical company focused on harnessing the body’s natural regulation of protein levels to develop novel medicines to target and destroy disease-causing proteins for the treatment of cancer and other diseases. This targeted protein degradation approach offers advantages over traditional therapies, including the potential to treat a wider range of diseases, reduce drug resistance, achieve higher potency, and decrease side effects through greater selectivity. We are excited to be building the organization that will take the next step in leading this new class of medicines from research into drug development and clinical trials. To learn more about C4 Therapeutics, visit www.C4Therapeutics.com.