UCSD Layoff from Career Appointment: Apply by 02/11/21 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor. Special Selection Applicants: Apply by 02/22/21. Eligible Special Selection clients should contact their Disability Counselor for assistance. This posting will remain open until filled. DESCRIPTIONThe Department of Medicine (DOM) is the largest department within the UCSD School of Medicine and is responsible for fulfilling the teaching, research, and clinical missions of the University of California, San Diego School of Medicine. The department employs approximately 500 salaried faculty, 168 academic appointees, 331 residents, fellow and postdocs and 479 staff personnel. The Advanced Cell Therapy lab is a state of the art cGMP manufacturing facility whose highly skilled team will support UC and local investigators transition novel therapies through the IND and Phase I/II clinical trials. Under general supervision, responsible for performing GMP (Good Manufacturing Practice) cell culture and the associated assays within a laboratory or clean room. Perform a broad range of laboratory activities in the support of cell therapy products under cGMP for use in pre-clinical & clinical studies. Undertakes translational research and development and validation studies of processes and equipment as required. Performs all associated CTL procedures that are required to ensure the daily operation of the CTL and to maintain CTL licensing and accreditation, as indicated. Responsible for participating in the quality management and accreditation process. Responsible for culturing T cells, NK cells, neuronal cells, stem cells, embryonic stem cells, and other cell types derived from donors. MINIMUM QUALIFICATIONSFive (5) years of related experience, education/training; OR a Bachelor's degree in related area plus one (1) year of related experience/training. Hands-on experience in a pharmaceutical, biotech, drug manufacturing, or academic environment is required, with knowledge of clean room practices being essential. Proven experience with aseptic cell culture methods, including cryopreserving, thawing, and expanding cell lines, is required. Proficient computer skills using MS Word, Excel and email. Demonstrated experience using basic laboratory equipment; knowledge of safe laboratory procedures. Strong organizational skills with ability to prioritize tasks and to work under the pressure of multiple demands. Ability to follow detailed instructions described in SOPs and batch records and to record data accurately and in a legible manner per cGMP requirements. Demonstrated ability to work with a variety of individuals including faculty, clinicians, and staff and to work as a team member in a support position. Willingness to work in environment where biological (including infectious agents and blood borne pathogens), chemical, and radiological hazards are present, to perform research on the human pluripotent stem cell, to work with viruses that are infectious to humans, including adeno-associated viruses, Sendai viruses, and lentiviral vectors which are derived from human immunodeficiency virus (HIV).
PREFERRED QUALIFICATIONS- Experience and knowledge in iPSC cell culture techniques, including culturing and maintenance.
- Familiarity with the Miltenyi CliniMACs device, flow cytometry, and PCR techniques.
SPECIAL CONDITIONS- Employment is subject to a criminal background check.
- Willingness to work in BioSafety Level II environment where biological (including infectious agents and blood borne pathogens) hazards are present.
- Willingness to work with embryonic stem cells, work with viruses that are infectious to humans, including adeno-associated viruses, Sendai viruses, and lentiviral vectors which are derived from human immunodeficiency virus (HIV).
- Willingness to adhere to established UCSD guidelines for safety and environmental issues.
- Must be able to work various hours and locations based on business needs.
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