| Summary Description: The laboratory of Dr. Andrew R. Marks, Chair, Department of Physiology and Cellular Biophysics at Columbia University Irving Medical Center, is seeking Postdoctoral Research Scientists (up to three positions available). Projects include: cryo-EM structures of RyR channels (with Nobel Laureate Joachim Frank and Wayne Hendrickson), calcium signaling in diabetes, engineering of nanosecond resolution channel recordings in planar lipid bilayers (with Ken Shepard from electrical engineering), molecular basis of inherited cardiomyopathies and heart failure, and calcium signaling in neurodegenerative diseases, drug discovery efforts to test novel therapeutics for heart, muscle, metabolic and CNS disorders. We are translating fundamental discoveries into ongoing clinical trials. Recent laboratory members have gone on to leading academic and pharmaceutical industry positions. Recent publications include:
Liu, X., Betzenhauser, M.J., Reiken, S., Meli, A.C., Arancio, O., Chen B.-X., Marks AR (2012) Role of Leaky Neuronal Ryanodine Receptors in Stress-Induced Cognitive Dysfunction Cell 150, 1055–1067.
Ran Zalk, Oliver B. Clarke, Amédée des Georges, Robert A. Grassucci, Steven Reiken, Filippo Mancia, Wayne A. Hendrickson, Joachim Frank, Marks, A.R. (2014) Structure of a mammalian ryanodine receptor Nature 2015 517(7532):44-9.
Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA
Excess TGF-Beta mediates muscle weakness associated with bone metastases in mice.
Nature Medicine, 2015 Nov;21(11):1262-1271.
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank, J Structural Basis for Gating and Activation of RyR1. Cell 2016 Sep 22;167(1):145-157
Liu, X., Betzenhauser, M.J., Reiken, S., Meli, A.C., Arancio, O., Chen B.-X., Marks AR (2012) Role of Leaky Neuronal Ryanodine Receptors in Stress-Induced Cognitive Dysfunction Cell 150, 1055–1067.
Ran Zalk, Oliver B. Clarke, Amédée des Georges, Robert A. Grassucci, Steven Reiken, Filippo Mancia, Wayne A. Hendrickson, Joachim Frank, Marks, A.R. (2014) Structure of a mammalian ryanodine receptor Nature 2015 517(7532):44-9.
Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA
Excess TGF-Beta mediates muscle weakness associated with bone metastases in mice.
Nature Medicine, 2015 Nov;21(11):1262-1271.
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank, J Structural Basis for Gating and Activation of RyR1. Cell 2016 Sep 22;167(1):145-157 |
