Researcher 4 - Vaccine & Antibody Development Chemistry Professional
University of Minnesota, Twin Cities
Location: Minneapolis, Minnesota
Salary: 42099.20 - 101025.60
Internal Number: 338450
We are in search of a well-rounded team player that is interested in interfacing with other members of the lab as well as managing relationships with several external collaborators including research institutes, start-ups and CMO/CDMOs for GMP manufacturing. The ideal candidate should execute tasks independently, have good managerial and communication skills, be creative, flexible, self-motivated, and exhibit problem solving skills.
75% Work independently to solve complex research-related projects in the laboratory. Responsible for the conjugation of small molecules to carriers using coupling chemistry (e.g., carbodiimide or maleimide), MALDI-TOF, dynamic light scattering (DLS) or other research methods to measure conjugate size, perform purification, scale-up, and release assays for conjugate vaccines to be used in animal studies. Creating and evaluating various conjugates prepared in lab and received from other labs including project-related troubleshooting, development, preparation and formulation of new compounds for testing. Ensure that components of projects are completed in an ethically, scientifically rigorous, and timely manner. Provide technical expertise to research lab staff regarding problem solving, experimental procedures, statistical analysis, and research project design. Review literature as suggested by the research. Select relevant facts, techniques, and procedures from the literature to advance research projects.
15% Responsible for administrative activities in support of research projects. Management activities of GMP manufacturing campaigns including cross-functional communication between third parties, establishing timelines and holding regular meetings to update the rest of the team about ongoing operations. Providing technical expertise (scientific or administrative) and support to outside collaborators on various projects as needed. Follow project execution and ensure results-delivery.
10% Responsible for technical writing in support of research projects. Responsible for drafting or reviewing Standard Operating Procedures (SOPs) for internal use or destined to third parties (CMO, CRO, research laboratories, or industry partners). Reviewing and/or drafting CDAs, SOWs, and other CPS-related legal and technical agreements. Writing or reviewing confidential or non-confidential study reports (manuscripts, posters, data presentations, etc.).
Bachelor's degree in the Biological Sciences (preferably in Medicinal Chemistry, Pharmaceutics, or similar) and 4 years of professional laboratory experience or a combination of related education and experience to equal eight years.
Expertise in conjugation chemistry is required. The candidate should have core expertise in the conjugation of small molecules (e.g., haptens and peptides) to carriers (e.g., proteins, nanoparticles), and their purification or formulation in suitable delivery vehicles (e.g., liposomes or adjuvants).
Master's Degree in the Biological Sciences (preferably in Medicinal Chemistry, Pharmaceutics, or similar) and 2 years of professional laboratory experience. Experience in vaccine development or antibody engineering, immunoassays and operation of MALDI TOF, DLS, LC/MS or equivalent instrument.
Other preferred skills include the ability to operate a Triple Quad LC/MS to conduct peptide or protein analysis.
Availability or experience in working with animals (rodents) is a plus.
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.