An Assistant Project Scientist research position is immediately available at the McDonald-Nandi laboratory (http://mcdonald-nandi.ech.ucdavis.edu), Department of Chemical Engineering, University of California, Davis to work on the projects that involve transgenically/transiently producing, quantifying, and characterizing pharmaceutical proteins in lettuce (Lactuca sativa) and tobacco (Nicotiana benthamiana). The successful candidate should have outstanding and appropriate research experience and should provide evidence of effective and innovative research in the areas listed below. The duration of this position is initially for one year and extendable depending on performance and availability of funding.
Specific tasks include but are not limited to:
Grow (preferably hydroponically) and maintain healthy lettuce and Nicotiana benthamiana plants.
Perform genetic infiltration and bombardment of target genes (and perhaps other methods) to produce both transgenic plants and transient expression in plants/leaves. Design of experiments to optimize speed of production, quantitative analyses and quality of recombinant proteins made in plants.
Grow selected transgenic lettuce lines expressing target proteins both in greenhouse and controlled environmental facilities.
Draft amendments to the lab Biological Use Authorization as needed.
Perform appropriate assays (ELISA, Western blots, and activity) to measure specific productivity of target recombinant proteins.
Generate a sufficient amount of viable seeds and leaves for purification and further characterization of the target recombinant proteins in crude extract or after purification (e.g. SDS-PAGE, Western, ELISA, amino acid sequence, activity assay, CD analysis, etc.).
Optimization of extraction and purification (>95%) of target molecules using centrifugation, TFF and AKTA systems and standardization of the protocols for scalability.
Supervise undergraduate and graduate students working on related projects in the laboratory.
Interface with collaborators within the university and outside of the university to further research objectives.
Prepare monthly research update presentations, drafts of journal publications, maintain laboratory notebooks and data, identify related research and fellowship funding opportunities, contribute to proposals, present research findings at conferences and internal meetings.
Please be aware that due to the ongoing COVID-19 pandemic, campus in-person operations have been restricted to essential personnel only. All academic and scholarly activities are being conducted remotely for the time being. As a result, interviews, seminars, and additional consultations may occur via remote platforms, including Zoom, to which we will provide access.
The position is open until filled; but to assure full consideration, applications should be submitted no later than 30 days of publication of this advertisement, for a start date as soon as possible/situation permits.
We strongly recommend that all candidates visit our website dedicated to this search for additional information about how their application materials, including their Statement of Contributions to Diversity, will be used by the Search Committee in our screening and review process. The link is https://academicaffairs.ucdavis.edu/statements_of_contributions_to_DEI
UC Davis is an affirmative action / equal opportunity employer, and is dedicated to recruiting a diverse faculty community. We welcome all qualified applicants to apply, including women, minorities, individuals with disabilities, and veterans.
UC Davis is the home of the Aggies — go-getters, change makers and problem solvers who make their mark at one of the top public universities in the United States. Since we first opened in 1908, we’ve been known for standout academics, sustainability and Aggie Pride as well as valuing the Northern California lifestyle. These themes are woven into our 100-plus-year history and our reputation for solving problems related to food, health, the environment and society.Our 5,300-acre campus is in the city of Davis, a vibrant college town of about 68,000 located in Yolo County. The state capital is 20 minutes away, and world-class destinations such as the San Francisco Bay Area, Lake Tahoe and the Napa Valley are within a two-hour drive.