An exciting opportunity is open for an experienced researcher to join the Dr. Anupriya Agarwal Laboratory at the OHSU Knight Cancer Institute as an Assistant Staff Scientist in Portland, OR.

Our laboratory focuses on identifying novel intrinsic- and extrinsic signaling pathways that are requisite for leukemia progression, clonal evolution, and drug resistance. The work will concentrate on the discovery and validation of new therapeutic targets in hematologic malignancies and the molecular characterization of signaling pathways involved in disease pathogenesis.

The position is in an interdisciplinary, collaborative, and highly translational environment in the OHSU Knight Cancer Institute and the Department of Hematology and Oncology in the OHSU School of Medicine. Highly-motivated candidates with expertise in molecular biology, hematopoiesis, cell signaling/ epigenetics, and in vivo models who are interested in a career in oncology basic/translational research will be most competitive for this position. Additional responsibilities include, but are not limited to:

• Maintaining a high level of professional expertise in the field;
• Designing and executing experiments;
• Establishing laboratory procedures and maintaining a high level of organization in the lab.

The individual should have demonstrated a distinguished record of scientific and technical accomplishments.

Key Responsibilities:

Laboratory Research (80%) : Develop and manage research experiments, determining the most suitable methods to be used, i ncluding identification of scientific problem, design of approach to address it . Interpret and perform complex data analysis on experimental results and determine whether they are consistent with goals. Maintain a high level of professional expertise through familiarity with current scientific literature. As needed, develop innovative techniques and experimental systems to meet Agarwal laboratory research program goals.

Scientific Writing and Project Proposal Development (15%) : Prepare research findings for presentation at scientific meetings and conference and manuscripts for publication. Prepare research project proposals for internal and external review, prepare annual or bi-annual research progress summaries and presentations.

Collaborative Interactions (5%) : W it h input from Dr. Agarwal, help to develop, foster and maintain relationships with partners in academia and in the pharmaceutical/biotechnology industries. Oversee the advancement of milestones of funded projects and ensure that external partners receive regular project updates.

Doctoral degree in relevant field and 3-5 years of relevant post-doctoral work experience.

Assistant Staff Scientists have at least 3 years of post-graduate research experience in the relevant field. They are likely to have deep expertise in a singular area of focus but may also have worked as boundary spanners across multiple fields. Achieving this position requires that the researcher has demonstrated a satisfactory track record of scholarly activity including high-quality peer-reviewed publications. This individual should have the potential to lead the projects in the Agarwal lab. In order to maintain successful track record and show potential of growth, the individual must be actively engaged in publishing high-quality manuscripts, the development and submission of grant/funding proposals and leading projects that are aligned with the labs focus area.

Other required competencies:

• Proficient with computers specifically MS Office (which includes, Excel, Access, Word and PowerPoint) and statistical analysis software.
• Strong publication record
• Experience handling chemical and biologically hazardous materials.
• Knowledge of policy and regulations applicable to the laboratory, including but not limited to safety, animal and radiation.
• Technical proficiency, scientific creativity collaborative ability, and independent thinker
• Proven ability to work collaboratively with a high performing work group
• Ability to prioritize multiple tasks at one time
• Must have excellent communication, analytical and organizational skills: both written and verbal
• Ability to work independently and as part of a team while being collaborative in resolving problems
• Demonstrated ability to learn new and innovative processed quickly
• Must possess energy and drive to coordinate multiple projects simultaneously
• Ability to use tact and diplomacy to maintain effective working relationships
• Ability to operate complex scientific equipment and develop and troubleshoot complex experimental protocols
• Demonstrated ability to build productive cross functional collaborations both internally and externally
• Ability to analyze short and long term project needs.
• Ability to schedule, manage and coordinate multiple projects and priorities simultaneously

• Expertise in cancer biology, molecular/hematopoiesis, and genomics
• Five or more years in a research position, including at least 4 years of supervisory and project management experience
• Experience with murine leukemia models is strongly preferred.
• Experience in hematopoiesis
• Experience in FACS based methods, biochemistry, and molecular biology
• Experience in analyzing the RNAseq /methylation/ pathway analyses or experience with large dataset analysis is preferred.

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