Lilly’s Drug Disposition team is searching for an experienced pharmaceutical scientist to lead in the application of absorption, distribution, metabolism, excretion (ADME) science to advance our portfolio. Working on cross-functional teams, our diverse group is multidisciplinary, utilizing in vitro, in vivo, and in silico approaches to mechanistically study the pharmacokinetics, absorption, and disposition of new chemical entities. You will serve as technical leader within the department and across portfolio cross-functional teams. This role will require engaging in experimental design and data interpretation to deliver the discovery and development portfolio of investigational targets and novel therapeutics. We are passionate about making an impact in the lives of our patients. Consider joining our efforts!
Accountable for the delivery of scientifically integrated data packages to guide compound selection, study design, and portfolio decisions.
Partner with cross-functional colleagues including Toxicology, PKPD, Biology and Medicinal Chemistry to assess and, where possible, ameliorate drugability and development risk through effectual data analyses and study conduct.
Lead R&D initiatives to grow ADME capabilities across experimental and drug modalities.
Integrate in vitro, in vivo, and in silico ADME data with Biology and Chemistry understanding to define structure-activity- and structure-property-relationships and deliver favorable molecular and experimental design strategies.
Prepare preclinical data packages to support global regulatory submissions and correspondence as well as represent ADME in face-to-face discussions with regulators.
Guide junior, peer, and upper level scientists in best and modern practices of multi-property optimization through the use of mechanistic ADME principles.
Collaborate and network efficiently across internal and external organizations.
Evaluate and apply innovative PBPK/MPK approaches to translate and predict human PK, using modeling as a tool to help generate hypotheses, design better studies, inform clinical plans and support registration.
Communicate the value of mechanistic ADME approaches both internally within R&D and externally including regulatory agencies.
Build a strong external network (e.g. academia, consortia) and keep up to date with emerging literature and science in the area.
D. degree in Drug Metabolism, Pharmacokinetics, or Pharmaceutics, or related field with extensive training in the field of drug metabolism and disposition of at least 5 years or more or
S. degree in above subject areas with at least 10 years of directly applicable experience in the field of drug metabolism and disposition.
Additional Skills/ Preferences
Experience in drug discovery and development, primarily/preferably small molecule.
Detailed understanding of pharmacokinetics, ADME and proficiency to communicate theory and concepts clearly
Ability to balance multiple projects and handle competing responsibilities.
Hands-on experience with modeling software (e.g. SimCYP, GastroPlus, PKSim)
Demonstrate strong communication skills with the ability to integrate diverse perspectives, adroitly deliver critical messaging, and influence leaders/key partners.
Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community.
Limited travel required for conferences, external reviews, and regulatory meetings
Internal Number: R-2339
About Eli Lilly and Company
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.