Essential Functions: Develop, validate, and implement LC-MS/MS methods to quantitatively determine small molecule drugs and metabolites in biological samples to support preclinical and clinical drug metabolism and pharmacokinetic studies.Develop and implement LC-MS/MS based methods for metabolomic profiling.Develop and implement novel sample preparation and separation strategies.Apply LC-MS/MS to identify chemical structures of unknown metabolites. Design and perform cell and biochemical based assays to measure cell growth/death pathways, metabolomics changes, and other mechanistic read-outs. Maintain cell cultures required for experiments.Participate in managing the day-to-day operations of a laboratory, including but not limited to, daily instrument maintenance. Organize and implement laboratory SOPs for sample processing and analysis.Participate in data analysis/interpretation and writing manuscripts for publication.
Qualifications: PhD degree in chemistry, biochemistry, pharmaceutical science, pharmacology or other appropriate discipline.At least 3-year laboratory experience with a strong background in analytical chemistry and molecular biology.Extensive experience in LC-MS/MS analysis.Experience in cell and molecular biology techniques, such as RT-PCR, ELISA, Western blot.Ability to work independently and communicate effectively.Ability to interpret and summarize scientific data in a clear, concise and accurate manner.Excellent organizational skills, with the ability to efficiently manage and prioritize multiple projects.Excellent oral and written communication skills
Internal Number: 76_208185
About Wayne State University
Founded in 1868, Wayne State University is a nationally recognized metropolitan research institution offering more than 400 academic programs through 13 schools and colleges to nearly 32,000 students. Wayne State?s main campus in Midtown Detroit comprises 100 buildings over nearly 200 acres; its five extension centers offer higher education to people throughout Southeast Michigan. Wayne State is dedicated to preparing students to excel by combining the academic excellence of a major research university with the practical experience of an institution that by its history, location and diversity represents a microcosm of the world we live in. Reflecting its location and the excellent international reputation of its graduate schools, particularly in the sciences, Wayne State boasts the most diverse student body among Michigan?s public universities. Its students represent 49 U.S. states and more than 60 countries.